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Research

Research

Research

Research is an integral part of Shriners Hospitals for Children — Boston. Our mission is to conduct research that will ultimately improve the timely and complete recovery of children with burns by enhancing and developing new therapeutic approaches for use during and following hospitalization.

Shriners Hospitals for Children — Boston is a leading research facility in biotechnical engineering, as well as other fields, housing approximately 30,000 square feet of research space and employing some 100 researchers. One-quarter of our research staff is on faculty at Harvard Medical School and their investigations are made possible by combinations of funding from The National Institutes of Health, The National Science Foundation, The Department of Defense, and philanthropic and industrial sources, as well as by Shriners Hospitals for Children’s internal research funding.

Highly advanced research equipment, such as a positron emission tomography (PET) machine, provides researchers with enhanced capabilities to explore metabolic disorders, psychological disorders post-injury and significant advances in the targeting of drugs to specific sites.

Our researchers are renowned worldwide as leaders in their fields, including:

In 2014, the research team in Boston published more than 140 papers covering a wide range of specialties. In the past decade, our researchers have authored nearly 10 percent of the papers presented at the American Burn Association’s annual meeting.

Recently published research papers include:

  • Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering. Kelley SO, Mirkin CA, Walt DR, Ismagilov RF, Toner M, Sargent EH. Nat Nanotechnol. 2014 Dec 3;9(12):969-980. doi: 10.1038/nnano.2014.261. Review. PubMed PMID: 25466541.
  • Collective and individual migration following the epithelial-mesenchymal transition. Wong IY, Javaid S, Wong EA, Perk S, Haber DA, Toner M, Irimia D. Nat Mater. 2014 Nov;13(11):1063-71. doi: 10.1038/nmat4062. Epub 2014 Aug 17. PubMed PMID: 25129619; PubMed Central PMCID: PMC4209198.
  • Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nat Med. 2014 Jul;20(7):790-3. doi: 10.1038/nm.3588. Epub 2014 Jun 29. PubMed PMID: Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta OB, Uygun BE, Izamis ML, Toner M, Yarmush ML, Uygun K. 24973919; PubMed Central PMCID: PMC4141719.
  • Microfluidic, marker-free isolation of circulating tumor cells from blood samples. Karabacak NM, Spuhler PS, Fachin F, Lim EJ, Pai V, Ozkumur E, Martel JM, Kojic N, Smith K, Chen PI, Yang J, Hwang H, Morgan B, Trautwein J, Barber TA, Stott SL, Maheswaran S, Kapur R, Haber DA, Toner MNat Protoc. 2014 Mar;9(3):694-710. doi: 10.1038/nprot.2014.044. Epub 2014 Feb 27. PubMed PMID: 24577360; PubMed Central PMCID: PMC4179254.
  • Organomatics and organometrics: Novel platforms for long-term whole-organ culture. Technology. Bruinsma BG, Yarmush ML, Uygun K (Singap World Sci). 2014 Mar;2(1):13. PubMed PMID: 25035864; PubMed Central PMCID Bruinsma BG, Yarmush ML, Uygun K.
   
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