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Orthopaedic, metabolic and musculoskeletal research

Orthopaedic, metabolic and musculoskeletal research

Research is an integral part of Shriners Hospitals for Children — St. Louis. Our mission is to discover new knowledge that improves the quality of care and the quality of life for children and their families.

The orthopaedic surgeons at the St. Louis Shriners Hospital are faculty members at Washington University School of Medicine, and have published more articles, textbooks and chapters than any other pediatric orthopaedic hospital in the nation.

Research contacts:

Clinical Research Infrastructure Core
Phone: 314-872-8342, ext. 1102
Email

Scott Luhmann, M.D.
Chief of Staff
Phone: 314-432-3600

Current clinical research studies taking place at Shriners Hospitals for Children — St. Louis

Spine

  • Treatment of Progressive Early Onset Spinal Deformities:  Multi-Center Outcome Study - Investigator: Scott Luhmann, M.D.
  • The Chest Wall and Spine Deformity Registry - Investigator: Scott Luhmann, M.D.

Upper extremity (hand, elbow, shoulder)

  • Repository of Congenital Anomalies of the Upper Extremity (CoULD) - Investigator: Charles Goldfarb, M.D.
  • Syndactyly reconstruction and contracture release in the hand treated with dermal substitute - Investigator: Lindley Wall, M.D.
  • Characterization of hand anomalies associated with MOBIUS Syndrome - Investigator: Lindley Wall, M.D.
  • Radiographic and Clinical Outcomes of the shoulder in long-term follow up of Birth Brachial Plexus Palsy - Investigator: Lindley Wall, M.D.

Hip/pelvis

  • Results of In Situ Fixation of Slipped Capital Femoral Epiphysis - Investigator: Jeffrey Nepple, M.D.

Lower extremity (leg, knee, foot)

  • Knee Pain and Activity Outcomes after Femoral Derotational Osteotomy for Excessive Femoral Anteversion - Investigator: J. Eric Gordon, M.D.
  • Patellar tendon transfer in the surgical treatment of patellar dislocation in the skeletally immature patient - Investigator: Jeffrey Nepple, M.D.

Research publications from Shriners Hospitals for Children — St. Louis

Pediatric Musculoskeletal Research Center

Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffold.
Huynh NPT, Brunger JM, Gloss CC, Moutos FT, Gersbach CA, Guilak F.
Tissue Eng Part A. 2018 Oct;24(19-20):1531-1544. doi: 10.1089/ten.TEA.2017.0510. Epub 2018 Jul 13.

Osteoarthritis as a disease of the cartilage pericellular matrix.
Guilak F, Nims RJ, Dicks A, Wu CL, Meulenbelt I.
Matrix Biol. 2018 Oct;71-72:40-50. doi: 10.1016/j.matbio.2018.05.008. Epub 2018 May 22. Review.

Metabolic & Molecular Research Center

Burosumab Therapy in Children with X-Linked Hypophosphatemia.
Carpenter TO, Whyte MP, Imel EA, Boot AM, Högler W, Linglart A, Padidela R, Van't Hoff W, Mao M, Chen CY, Skrinar A, Kakkis E, San Martin J, Portale AA.
N Engl J Med. 2018 May 24;378(21):1987-1998. doi: 10.1056/NEJMoa1714641.

Sclerosteosis: Report of type 1 or 2 in three Indian Tamil families and literature review.
Whyte MP, Deepak Amalnath S, McAlister WH, Pedapati R, Muthupillai V, Duan S, Huskey M, Bijanki VN, Mumm S. 
Bone. 2018 Nov;116:321-332. doi: 10.1016/j.bone.2018.07.022. Epub 2018 Aug 2.

Rehabilitation Therapy

Development and validation of a modified performance-oriented mobility assessment tool for assessing mobility in children with hypophosphatasia.
Phillips D, Griffin D, Przybylski T, Morrison E, Reeves AL, Vallee M, Fujita KP, Madson KL.
J Pediatr Rehabil Med. 2018;11(3):187-192.doi: 10.3233/PRM-170523.

Orthopaedic Research

Hip/Pelvis

Development of the HOOS global to Assess Patient-Reported Outcomes in Patients Undergoing Hip Preservation Procedures. 
Jacobs CA; Peabody MR; Duncan ST; Muchow RD; Nunley RM; ANCHOR Group; Clohisy JC; Beaule PE; Kim YJ; Millis MB; Podeszwa DA; Schoenecker PL; Sierra RJ; Sink EL; Sucato DJ; Trousdale RT; Zaltz I.
American Journal of Sports Medicine. 46(4):940-946, 2018 Mar.

Acetabular Focal Chondral Lesions Are Not Associated With Worse Outcomes After Periacetabular Osteotomy: A Matched Group Analyses. 
Hellman MD; Nepple JJ; Pascual-Garrido C; Sierra RJ; Clohisy JC; ANCHOR Study
Journal of Arthroplasty. 33(7S):S61-S65, 2018 Jul.

Lower Extremity (leg, knee, foot)

Knee Pain and Activity Outcomes After Femoral Derotation Osteotomy for Excessive Femoral Anteversion.
Stambough JB; Davis L; Szymanski DA; Smith JC; Schoenecker PL; Gordon JE.
Journal of Pediatric Orthopedics. 38(10):503-509, 2018 Nov/Dec.

Opioid Use Following Operatively Treated Pediatric Elbow and Femur Fractures.
Meyer ZI; Krucylak P; Mo M; Miller ML; Wall LB.
Journal of Pediatric Orthopedics.  2018 Nov 13.

Upper Extremity (hand, elbow, shoulder)

Surgical transposition for chronic instability of the extensor carpi ulnaris tendon.
Fram B; Wall LB; Gelberman RH; Goldfarb CA.
Journal of Hand Surgery: European Volume. 43(9):925-930, 2018 Nov.

Camptodactyly Treatment for the Lesser Digits. [Review]
Wall LB; Ezaki M; Goldfarb CA.
Journal of Hand Surgery - American Volume. 43(9):874.e1-874.e4, 2018 Sep.

Spine

Organ System Anomalies Associated With Congenital Scoliosis: A Retrospective Study of 305 Patients.
Furdock R; Brouillet K; Luhmann SJ.
Journal of Pediatric Orthopedics.  2018 Oct 29.

Complications of Posterior Column Osteotomies in the Pediatric Spinal Deformity Patient.
Sze CH; Smith JC; Luhmann SJ.
Spine Deformity. 6(6):656-661, 2018 Nov - Dec.