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Orthopaedic research

Orthopaedic research

Research is an integral part of Shriners Hospitals for Children — St. Louis. Our mission is to discover new knowledge that improves the quality of care and the quality of life for children and their families.

The orthopaedic surgeons at the St. Louis Shriners Hospital are faculty members at Washington University School of Medicine, and have published more articles, textbooks and chapters than any other pediatric orthopaedic hospital in the nation.

Research contacts:

Clinical Research Infrastructure Core
Phone: 314-872-8342, ext. 1102

Scott Luhmann, M.D.
Chief of Staff
Phone: 314-432-3600

Current clinical research studies taking place at Shriners Hospitals for Children — St. Louis:

  • Duration of Brace Wear in Clubfoot Treatment - A Prospective Randomized Trial
  • A CAT Platform for Assessment of Physical Functioning of Children with Cerebral Palsy
  • BrAIST II - Bracing Adolescent Idiopathic Scoliosis Trial
  • Monitoring For Osteoclast Failure From Bisphosphonate Toxicity In The Treatment Of Pediatric Osteoporoses
  • X-Linked Hypophosphatemia and Hypophosphastasia During Adult Life
  • Vitamin B6 Loading Study to Identify Carriers and Patients with Hypophosphatasia
  • Studies in Metabolic Bone Disease in Adults and Children
  • Studies in Metabolic Bone Disease (Bone Disease from Chemical Imbalance): Family Study of Patients with Metabolic Bone Diseases.
  • Calcitriol Therapy for Hypophosphatemic Rickets
  • Characterization of the X-Linked Hypophosphatemia & X-Linked Recessive Hypoparathyroidism Gene; Two X-Linked Genes That Regulate Mineral Homeostasis
  • ENB-009-10: A Randomized, Open-Label, Multicenter, Multinational, Dose-Ranging, Concurrent Control Study of the Safety, Efficacy and Pharmacokinetics of ENB-0040 in Adolescents and Adults with HPP
  • ENB-008-10: Extension Study of Protocol ENB-006-09 Evaluating the Long-Term Safety and Efficacy of ENB-0040 (Human Recombinant Tissue-Nonspecific Alkaline Phosphatase Fusion Protein) in Children with Hypophosphatasia (HPP)
  • A Retrospective, Non-Interventional, Epidemiologic Study of the Natural History of Patients with Juvenile-Onset Hypophosphatasia (Hpp)
  • ENB-006-09: A Randomized, Open-Label, Multicenter, Multinational, Dose-Ranging, Historical Control Study of the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of ENB-0040 (Human Recombinant Tissue Nonspecific Alkaline Phosphatase Fusion Protein) in Children
  • Washington University Joint Reconstruction Surgery Repository
  • Joint Preservation Hip Surgery Repository
  • Outcome of Surgical results in treatment of Residual Clubfoot deformity management & classification of Tibial Tubercle Fractures
  • Fox Pediatric Spinal Deformity Study
  • Best Practice Guidelines Validation Study
  • Pulmonary Function and Clinical Outcomes of Skeletally Mature Patients with early onset scoliosis
  • Outcomes & Knee functional Scores after Surgery for Discoid Meniscus in Pediatric Patients
  • Proximal Junctional Kyphosis in Adolescent Idiopathic Scoliosis
  • Patellar Tendon Transfer in Surgical Treatment of Patellar Dislocations in the skeletally immature patient
  • Surgical Wound Problems at the knee in pediatric and adolescent patients: Comparison Vicryl and PDS subcutaneous closure
  • Knee Pain and Activity Outcomes after Femoral Derotational Osteotomy for Excessive Femoral Anteversion
  • Outcomes & Complications related to Patellar Realignment surgery for patellar instability in adolescents
  • The Rate of Arthrofibrosis in Children with Tibial Eminence Fractures
  • Efficacy of intra-operative spinal cord monitoring w for pediatric patients with spinal cord pathology undergoing spinal deformity surgery
  • Outcome at a minimum of 2 years after knee osteochondral autograft or allograft in adolescent patients Unstable Discoid Menisci
  • Results & Complications of Oblique Tibial Osteotomies for Tibia Vara
  • Results & Complications After Femoral Lengthening over a Nail in pediatric patients
  • Vertical Expandable Prosthetic Rib
  • Proximal Junctional Kyphosis in Distraction-Based Growing Rods
  • Arthroscopic Lateral Release for Recalcitrant adolescent Medial Patellofemoral knee Pain
  • Tibial Lengthening in the Treatment of Posterior Medial Bowing of the tibia
  • Vertebral Body Stapling for Idiopathic Scoliosis
  • Treatment of Progressive Early Onset Spinal Deformities: Multi-center Outcome Study
  • Derotational Osteotomies for Malicious Malalignment in Cerebral palsy
  • Pediatric Femur Research Project
  • Comparison of Treatment Methods for Femur Fractures in Children <6y/o: spica versus titanium elastic nails
  • Patellar Tendon Transfer in the surgical Treatment of Patellar Dislocations in the skeletally immature patient
  • Assessment of Shoulder Balance During Surgery
  • Comparative Complications & Outcomes after Hemiepiphysiodesis using Staples vs. 8-plates
  • Treatment of Bount’s Disease with Taylor spatial frame & tightening of the Lateral Collateral Ligament
  • Comparison of Ilizarov External Fixator and Taylor Spatial Frame in the Treatmetn of Tibia Vara
  • The Chest Wall and Spine Deformity Registry
  • A Retrospective Review of Forearm Fractures in Children
  • BrAIST – Bracing Adolescent Idiopathic Scoliosis Trial
  • Comparing Treatment for Congenital Vertical Talus

Recently published research papers include:

Perry L. Schoenecker, M.D.

Martin Boyer, M.D.

John Clohisy, M.D.

Charles Goldfarb, M.D.

J. Eric Gordon, M.D.

Pooya Hosseinzadeh, M.D.

Jeffrey Johnson, M.D.

Martin Keller, M.D.

  • Pectus carinatum. Desmarais TJ, Keller MS, Curr Opin Pediatr. 2013 Jun; 25(3)375-81. doi: 10.1097/MOP.0b013e3283604088. 
  • View more of Dr. Keller’s research on his Washington University School of Medicine academic profile.

Michael P. Whyte, M.D.

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