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Orthopaedic research

Orthopaedic research

Research is an integral part of Shriners Hospitals for Children — St. Louis. Our mission is to discover new knowledge that improves the quality of care and the quality of life for children and their families.

The orthopaedic surgeons at the St. Louis Shriners Hospital are faculty members at Washington University School of Medicine, and have published more articles, textbooks and chapters than any other pediatric orthopaedic hospital in the nation.

Research contacts:

Clinical Research Infrastructure Core
Phone: 314-872-8342, ext. 1102

Scott Luhmann, M.D.
Chief of Staff
Phone: 314-432-3600

Current clinical research studies taking place at Shriners Hospitals for Children — St. Louis


  • Treatment of Progressive Early Onset Spinal Deformities:  Multi-Center Outcome Study - Investigator: Scott Luhmann, M.D.

Upper extremity (hand, elbow, shoulder)

  • Syndactyly reconstruction and contracture release in the hand treated with dermal substitute - Investigator: Lindley Wall, M.D.
  • Characterization of hand anomalies associated with MOBIUS Syndrome - Investigator: Lindley Wall, M.D.
  • Radiographic and Clinical Outcomes of the shoulder in long-term follow up of Birth Brachial Plexus Palsy - Investigator: Lindley Wall, M.D.


  • Results of In Situ Fixation of Slipped Capital Femoral Epiphysis - Investigator: Jeffrey Nepple, M.D.

Lower extremity (leg, knee, foot)

  • Knee Pain and Activity Outcomes after Femoral Derotational Osteotomy for Excessive Femoral Anteversion - Investigator: J. Eric Gordon, M.D.
  • Patellar tendon transfer in the surgical treatment of patellar dislocation in the skeletally immature patient - Investigator: Jeffrey Nepple, M.D.

Research publications from Shriners Hospitals for Children – St. Louis

Pediatric Musculoskeletal Research Center

Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.

Cao C, Ren Y, Barnett AS, Mirando AJ, Rouse D, Mun SH, Park-Min KH, McNulty AL, Guilak F, Karner CM, Hilton MJ, Pitt GS.

JCI Insight. 2017 Nov 16;2(22). pii: 95512. doi: 10.1172/jci.insight.95512. [Epub ahead of print]

CXCL10 is upregulated in synovium and cartilage following articular fracture.

Furman BD, Kent CL, Huebner JL, Kraus VB, McNulty AL, Guilak F, Olson SA.

J Orthop Res. 2017 Sep 14. doi: 10.1002/jor.23735. [Epub ahead of print]

Metabolic & Molecular Research Center

Gnathodiaphyseal dysplasia: Severe atypical presentation with novel heterozygous mutation of the anoctamin gene (ANO5).

Otaify GA, Whyte MP, Gottesman GS, McAlister WH, Eric Gordon J, Hollander A, Andrews MV, El-Mofty SK, Chen WS, Novack DV, Stolina M, Woo A, Katsonis P, Lichtarge O, Zhang F, Shinawi M.

Bone. 2017 Nov 21. pii: S8756-3282(17)30431-3. doi: 10.1016/j.bone.2017.11.012. [Epub ahead of print]

Alkaline Phosphatase: Discovery and Naming of Our Favorite Enzyme.

Siller AF, Whyte MP.

J Bone Miner Res. 2017 Jul 20. doi: 10.1002/jbmr.3225. [Epub ahead of print]

Rehab Therapy

Infant crawling orthosis and home program to strengthen a neurologically impaired upper extremity.

Graessle E

J Hand Ther. 2017 Jun 30. pii: S0894-1130(17)30138-2. doi: 10.1016/j.jht.2017.05.014. [Epub ahead of print]

Orthopedic Research


Age and Early Revision After Primary Total Hip Arthroplasty for Osteoarthritis.

Meyer Z; Baca G; Rames R; Barrack R; Clohisy J; Nam D.

Orthopedics. 40(6):e1069-e1073, 2017 Nov 01.

Developmental Dysplasia of the Hip: Contemporary Concepts and Treatment Innovations.

Clohisy JC.

Journal of Arthroplasty. 32(9S):S18-S19, 2017 Sep.

Femoral Morphology in the Dysplastic Hip: Three-dimensional Characterizations With CT.

Wells J; Nepple JJ; Crook K; Ross JR; Bedi A; Schoenecker P; Clohisy JC.

Clinical Orthopaedics & Related Research. 475(4):1045-1054, 2017 Apr.

Lower Extremity (leg, knee, foot)

The Community Orthopaedic Surgeon Taking Trauma Call: Pediatric Femoral Shaft Fracture Pearls and Pitfalls.

Gordon JE; Mehlman CT.

Journal of Orthopaedic Trauma. 31 Suppl 6:S16-S21, 2017 Nov.

Management of Clubfoot Relapses With the Ponseti Method: Results of a Survey of the POSNA Members.

Hosseinzadeh P; Kiebzak GM; Dolan L; Zionts LE; Morcuende J.

Journal of Pediatric Orthopedics. , 2017 Feb 07.

Delayed Wound Dehiscence of Anterior Knee Incisions in Patients Aged 20 Years and Younger: A Comparison of Subcutaneous Skin Closure.

Salib CG; Smith JC; Siow N; Luhmann SJ.

Journal of Pediatric Orthopedics. 37(8):543-546, 2017 Dec.

Upper Extremity (hand, elbow, shoulder)

The Prevalence of Congenital Hand and Upper Extremity Anomalies Based Upon the New York Congenital Malformations Registry.

Goldfarb CA; Shaw N; Steffen JA; Wall LB.

Journal of Pediatric Orthopedics. 37(2):144-148, 2017 Mar.

Intraobserver and Interobserver Reliability of the Oberg-Manske-Tonkin (OMT) Classification: Establishing a Registry on Congenital Upper Limb Differences.

Bae DS; Canizares MF; Miller PE; Roberts S; Vuillermin C; Wall LB; Waters PM; Goldfarb CA.

Journal of Pediatric Orthopedics. 38(1):69-74, 2018 Jan.


Serious Adverse Events Significantly Reduce Patient-Reported Outcomes at 2-Year Follow-up: Nonoperative Multicenter Prospective NIH Study of 105 Patients.

Pugely AJ; Kelly MP; Baldus CR; Gao Y; Zebala L; Shaffrey C; Glassman S; Boachie-Adjei O; Parent S; Lewis S; Koski T; Edwards C 2nd; Schwab F; Bridwell KH.

Spine., 2017 Oct 31.

Nasal Swab Screening for Staphylococcus aureus in Spinal Deformity Patients Treated With Growing Rods.

Luhmann SJ; Smith JC.

Journal of Pediatric Orthopedics. , 2017 Jun 13.